The enzyme(s) now commonly referred to as allene oxide synthase(AOS), CYP74 was reported in 1966 as an activity in flaxseed that metabolizedlinoleic acid hydroperoxide to an alfa-ketol derivative. Early publicationsestablished that other associated products from unsaturated fattyacid hydroperoxides are y-ketols and cyclopentenone fatty acids. Thesederivatives are now recognized to arise by hydrolysis and rearrangementsof the initial enzymic product, the very unstable allene oxide. The early literature refers to AOS as "hydroperoxide isomerase '' or "hydroperoxide cyclase, ''and "hydroperoxide dehydrase" has also b e e nused...

Source: Methods in Enzymology (1996) Vol 272, p. s 250-259